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[Combined effects of hypoxia and hypercapnia on the functional state of the respiratory center].
Metadata
JournalBiull Eksp Biol MedNot FoundDate
1975-Apr
Publication Type
Journal Article
Volume
1975-Apr / 79 : 39-43
Author
Kulik AM , Kondrat'eva LN
Doi
Not Found
PMIDMESH
Animals
Carbon Dioxide
Cats
Cheyne-Stokes Respiration
Diaphragm
Electrophysiology
Hydrogen-Ion Concentration
Hypercapnia
Hypoxia
Intercostal Muscles
Neurons
Oxygen
Respiratory Center
Abstract
Experiments were conducted on cats under nembutal anesthesia; a study was made of pulse activity of bulbar respiratory neurons, electrical activity of the diaphragm and of the intercostal muscles; pO2, pCO2, pH, arterial blood oxygen saturation were determined in combined action of hypoxia and hypercapnia. When hypoxic gaseous mixture was given for respiration the developing hypocapnia disturbed the discharge rhythmic activity of the respiratory neurons, the respiration acquiring a pathological character of the Cheyne--Stokes type. After addition to the hypoxic gaseous mixture of 2% CO2 the gaseous composition of the arterial blood approached the initial values; this addition prevented the development of hypercapnia and disturbances of rhythmic discharge activity of the respiratory neurons. Addition of 5% CO2 to the hypoxic gaseous mixture produced a negative effect: at first it intensified and then depressed the pulse activity of the respiratory neurons, caused metabolic and respiratory acidosis, and promoted asphyxia.
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Biull Eksp Biol MedBiulleten' eksperimental'noi biologii i meditsiny
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