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[Level of nicotinamide coenzymes in the myocardium of rats during the effects of methylxanthines (theophylline, theobromine, caffeine) and catecholamines].
Metadata
JournalBiull Eksp Biol MedNot FoundDate
1975-Apr
Publication Type
Journal Article
English Abstract
Volume
1975-Apr / 79 : 68-71
Author
Frantsuzova SB
Doi
Not Found
PMIDMESH
Animals
Caffeine
Epinephrine
Female
Heart
Isoproterenol
Male
Myocardium
NAD
NADP
Norepinephrine
Rats
Stimulation, Chemical
Theobromine
Theophylline
Abstract
It was shown in acute experiments on rats that one hour after an intraperitoneal injection of theophylline (50 mg/kg) there was a decrease in the NAD + NADP content by 19.4%, a tendency to a fall of NAD.H2 + NADP.H2 was expressed, and the total nicotinamide coferment level was reduced. A tendency to decrease NAD + NADP and the total pyridine nucleotide level was seen after caffeine administration. The action of catecholamines and methylxanthines was compared. Theobromine produced no significant effect on the indices under study. It was shown that isadrine decreased the NAD + NADP level; adrenaline (25 mkg/kg) increased the content of both the oxidized (by 24%) and of the reduced (by 48%) forms of pyridine nucleotides. An increase of adrenaline dose to 1000 mkg/kg was accompanied by reduction of the oxidized forms (by 22.2%) and of the total nicotinamide coferment level (by 18%).
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Biull Eksp Biol MedBiulleten' eksperimental'noi biologii i meditsiny
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