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Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study.
Metadata
Journalamerican journal of clinical nutrition6.766Date
2001-Oct
Type
Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't
Journal Article
Volume
2001-Oct / 74 : 549-54
Author
Chan JM 1, Stampfer MJ , Ma J , Gann PH , Gaziano JM , Giovannucci EL
Affiliation

No Data

Doi
PMIDMESH
Calcium, Dietary
Dairy Products
Diet Surveys
Humans
Male
Middle Aged
Physicians
Prospective Studies
Prostatic Neoplasms
Risk Factors
Surveys and Questionnaires
Abstract
BACKGROUND: A high calcium intake, mainly from dairy products, may increase prostate cancer risk by lowering concentrations of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], a hormone thought to protect against prostate cancer. The results of epidemiologic studies of this hypothesis are inconclusive.
OBJECTIVE: We investigated the association between dairy product and calcium intakes and prostate cancer risk in the Physicians' Health Study, a cohort of male US physicians.
DESIGN: At baseline, the men answered abbreviated dietary questionnaires. During 11 y of follow-up, we documented 1012 incident cases of prostate cancer among 20885 men. We estimated dairy calcium intake on the basis of consumption of 5 major dairy products and used logistic regression to estimate relative risk.
RESULTS: At baseline, men who consumed >600 mg Ca/d from skim milk had lower plasma 1,25(OH)(2)D(3) concentrations than did those consuming < or =150 mg Ca/d [71 compared with 85 pmol/L (30.06 compared with 35.64 pg/mL); P = 0.005]. Compared with men consuming < or =0.5 daily servings of dairy products, those consuming >2.5 servings had a multivariate relative risk of prostate cancer of 1.34 (95% CI: 1.04, 1.71) after adjustment for baseline age, body mass index, smoking, exercise, and randomized treatment assignment in the original placebo-controlled trial. Compared with men consuming < or =150 mg Ca/d from dairy products, men consuming >600 mg/d had a 32% higher risk of prostate cancer (95% CI: 1.08, 1.63).
CONCLUSIONS: These results support the hypothesis that dairy products and calcium are associated with a greater risk of prostate cancer.
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6.8
Am J Clin Nutramerican journal of clinical nutrition
Metadata
LocationUnited States
FromOXFORD UNIV PRESS

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