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Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord.
Metadata
Journalbrain research2.733Date
1975-Dec-19
Publication Type
Journal Article
Volume
1975-Dec-19 / 100 : 327-41
Author
Sonnhof U , Grafe P , Krumnikl J , Linder M , Schindler L
DoiPMIDMESH
Alanine
Amino Acids
Animals
Anura
Depression, Chemical
Drug Interactions
Evoked Potentials
Glycine
Membrane Potentials
Motor Neurons
Neural Inhibition
Neurotransmitter Agents
Picrotoxin
Rana esculenta
Spinal Cord
Spinal Nerve Roots
Stereoisomerism
Strychnine
Synaptic Membranes
Taurine
gamma-Aminobutyric Acid
Abstract
The actions of glycine, GABA, alpha-alanine, beta-alanine and taurine were studied by intracellular recordings from lumbar motoneurons of the isolated spinal cord of the frog. All amino acids tested produced a reduction in the amplitude of postsynaptic potentials, a blockade of the antidromic action potential and an increase of membrane conductance. Furthermore, membrane polarizations occurred, which were always in the same direction as the IPSP. All these effects indicate a postsynaptic inhibitory action of these amino acids. When the relative strength of different amino acids was compared, taurine had the strongest inhibitory potency, followed by beta-alanine, alpha-alanine, GABA and glycine. Topically applied strychnine and picrotoxin induced different changes of post-synaptic potentials, indicating that distinct inhibitory systems might be influenced by these two convulsants. Interactions with amino acids showed that picrotoxin seletively diminished the postsymaptic actions of GABA, while strychnine reduced the effects of taurine, glycine, alpha- and beta-alanine. But differences in the susceptibility of these amino acid actions to strychnine could be detected: the action of taurine was more sensitively blocked by strychnine compared with glycine, alpha- and beta-alanine. With regard to these results the importance of taurine and GABA as transmitters of postsynaptic inhibition on motoneurons in the spinal cord of the frog is discussed.
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Brain Resbrain research
Metadata
LocationNetherlands
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