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Respiratory effects of H+ and dinitrophenol injections into the brain stem subarachnoid space of fetal lambs.
Metadata
Journalcanadian journal of physiology and pharmacology1.946Date
1975-Oct
Publication Type
Journal Article
Volume
1975-Oct / 53 : 726-33
Author
Jansen AH , Russell BJ , Chernick V
DoiPMIDMESH
Animals
Blood Pressure
Brain Stem
Denervation
Dinitrophenols
Female
Fetus
Heart Rate
Hydrogen-Ion Concentration
Male
Oxygen Consumption
Pregnancy
Sheep
Subarachnoid Space
Abstract
Mock cerebrospinal fluid (pH 5.37-8.38) or 2,4-dinitrophenol (DNP) (0.15-1.5 mg) was injected into the subarachnoid space of the ventral brain stem of exteriorized fetal sheep. Changes in pH on the ventral surface of the medulla did not stimulate respiratory efforts or induce significant cardiovascular changes. The respiratory response to DNP injections ranged from no response to prolonged rhythmic ventilation that was independent of the peripheral chemoreceptors or the control arterial pH and blood gas tensions. This inconsistency suggests an effector site somewhat removed from the immediate surface of the medulla. The heart rate and blood pressure were not affected. It is concluded that increased H+ concentration in the extracellular fluid of the fetal ventral medulla does not initiate respiration, and any respiratory response to metabolic inhibitors applied to this area therefore is not attributable to a secondary change in surface pH.
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1.9
Can J Physiol Pharmacolcanadian journal of physiology and pharmacology
Metadata
LocationCanada
FromCANADIAN SCIENCE PUBLISHING

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