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Fluorometric assay for N-acetylprocainamide.
Metadata
Journalclinical chemistry7.292Date
1975-Dec
Publication Type
Journal Article
Volume
1975-Dec / 21 : 1899-902
Author
Matusik E , Gibson TP
Doi
Not Found
PMIDMESH
Humans
Hydrogen-Ion Concentration
Procainamide
Spectrometry, Fluorescence
Abstract
We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective lenear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 +/- 3.0% and 98.0 +/- 4.0%, respectively. For determination of either compound, the maximum coefficient of variation was 10%.
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7.3
Clin Chemclinical chemistry
Metadata
LocationEngland
FromOXFORD UNIV PRESS INC

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