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[Ebola and Marburg viruses: the humans strike back].
Metadata
Journalm s-medecine sciences0.692Date
2006-Apr
Type
Review
Journal Article
Volume
2006-Apr / 22 : 405-10
Author
Alazard-Dany N 1, Ottmann Terrangle M , Volchkov V
Affiliation

No Data

Doi
PMIDMESH
Africa, Central
Animals
Cathepsin B
Cathepsin L
Cathepsins
Containment of Biohazards
Cysteine Endopeptidases
Disease Outbreaks
Ebola Vaccines
Ebolavirus
Endosomes
Genome, Viral
Guinea Pigs
Hemorrhagic Fever, Ebola
Humans
Marburg Virus Disease
Marburgvirus
Membrane Fusion
Mice
Primates
Quarantine
Vaccines, Synthetic
Vesicular stomatitis Indiana virus
Viral Envelope Proteins
Viral Vaccines
Abstract
Ebola and Marburg viruses are the causative agents of rapidly progressive hemorrhagic fevers with high mortality rates. Pre- or post-exposure treatments against the diseases are currently not available for human use. In the field, establishment of strict quarantine measures preventing further virus transmission are still the only way to fight the infections. However, our knowledge of Ebola and Marburg viruses has markedly increased as a result of two recent discoveries discussed in this review. Chandran et al. have elucidated the mechanism by which Ebola GP is converted to a fusion-active form. Infectivity of Ebola virus was shown to be dependent on the cleavage of GP by cellular endosomal proteases, cathepsin B and L, thus opening new therapeutic approaches options. As for Jones SM et al., they have successfully vaccinated monkeys with recombinant vesicular stomatitis virus expressing Ebola or Marburg virus surface glycoprotein GP, a promising vaccine approach.
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Med Sci (Paris)m s-medecine sciences
Metadata
LocationFrance
FromEDP SCIENCES S A

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