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Anaerobic glycolysis in normal human erythrocytes incubated in vitro with sodium salicylate.
Metadata
JournalClin Sci Mol MedNot FoundDate
1975-Nov
Publication Type
Journal Article
Volume
1975-Nov / 49 : 375-84
Author
Worathumrong N , Grimes AJ
DoiPMIDMESH
Adenosine Diphosphate
Adenosine Monophosphate
Adenosine Triphosphate
Blood Glucose
Dose-Response Relationship, Drug
Erythrocytes
Glycolysis
Hematocrit
Humans
Hydrogen-Ion Concentration
In Vitro Techniques
Lactates
Phosphates
Potassium
Pyruvates
Sodium
Sodium Salicylate
Abstract
1. Some effects of sodium salicylate upon anaerobic glycolysis have been studied in normal human erythrocytes incubated for up to 6 h at 37 degrees C in autologous sera. 2. Both glucose consumption and lactate production were stimulated by concentrations of salicylate up to 60 mmol/l but at the highest concentration used (90 mmol/l) an initial stimulus was followed by inhibition of glycolysis. 3. Losses occurred of adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP) and adenosine 5'-phosphate(AMP)at higher concentrations of salicylate and there was a concomitant increase of inorganic phosphate. 4. Other phosphate esters underwent concentration changes at higher concentrations of salicylate that reflected inadequate concentrations of ATP for glycolysis. 5. The rates of sodium efflux from, and potassium influx into, erythrocytes were unaffected by the presence of salicylate at concentrations sufficient to stimulate glycolysis.
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