MedicGo
Effect of etafenone on total and regional myocardial blood flow.
Metadata
JournalArzneimittelforschungNot FoundDate
1975-Sep
Publication Type
Journal Article
Volume
1975-Sep / 25 : 1400-3
Author
Flohr H , Breull W
Doi
Not Found
PMIDMESH
Animals
Blood Pressure
Carbon Dioxide
Cardiac Output
Coronary Circulation
Coronary Vessels
Dogs
Heart Rate
Heart Septum
Heart Ventricles
Hydrogen-Ion Concentration
Hypoxia
Oxygen
Propiophenones
Vasodilator Agents
Abstract
The distribution of blood flow to the subendocardial, medium and subepicardial layers of the left ventricular free wall was studied in anaesthetized dogs under normoxic (A), hypoxic (B) conditions and under pharmacologically induced (etafenone) coronary vasodilation (C). Regional myocardial blood flow was determined by means of the particle distribution method. In normoxia a transmural gradient of flow was observed, with the subendocardial layers receiving a significantly higher flow rate compared with the subepicardial layers. In hypoxia induced vasodilation this transmural gradient of flow was persistent. In contrast a marked redistribution of regional flow was observed under pharmacologically induced vasodilation. The transmural gradient decreased. In contrast to some findings these experiments demonstrate that a considerable vasodilatory capacity exists in all layers of the myocardium and can be utilized by drugs. The differences observed for the intramural distribution pattern of flow under hypoxia and drug induced vasodilation support the hypothesis that this pattern reflects corresponding gradients of regional myocardial metabolism.
Fav
Like
Download
Share
Export
Cite
A
ArzneimittelforschungArzneimittel-Forschung
Metadata
Location
From

No Data

© 2017 - 2020 Medicgo
Powered by some medical students