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Influence of a new virostatic compound on the induction of enzymes in rat liver.
Metadata
JournalArzneimittelforschungNot FoundDate
1975-Sep
Publication Type
Journal Article
Volume
1975-Sep / 25 : 1426-9
Author
Kröger H , Donner I , Skiello G
Doi
Not Found
PMIDMESH
Adrenalectomy
Animals
Antiviral Agents
Cortisone
Culture Techniques
Dose-Response Relationship, Drug
Enzyme Induction
Female
Imidazoles
Liver
Piperazines
Rats
Time Factors
Tryptophan Oxygenase
Tyrosine
Tyrosine Transaminase
Abstract
The virostatic compound N,N-diethyl-4-[2-(2-oxo-3-tetradecyl-1-imidazolidinyl)-ethyl]-1-piperazinecarboxamide-hydrochloride (5531) was analyzed as to its effect on the induction of tryptophan-pyrrolase and tyrosineaminotransferase in rat liver. 1. The basic activity of the enzymes was not influenced by the substance either in normal or in adrenalectomized animals. 2. The induction of the enzymes by cortisone increased in the presence of the compound whereas the substrate induction remained unchanged. 3. The induction of tyrosine-aminotransferase by dexamethasonephosphate in tissue culture is inhibited if the dose of compound 5531 is higher than 5 mug/ml.
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ArzneimittelforschungArzneimittel-Forschung
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