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Spatially resolved transcriptomics and beyond.
Metadata
Journalnature reviews genetics33.133Date
2014 Dec 02
6 years ago
Publication Type
Review
Research Support, Non-U.S. Gov't
Volume
2015-01 / 16 : 57-66
Author
Crosetto N 1, Bienko M 1, van Oudenaarden A 2
Affiliation
  • 2. Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
Doi
PMIDMESH
Gene Expression Profiling
High-Throughput Screening Assays
Molecular Imaging
Sequence Analysis
Single-Cell Analysis
Spatial Analysis
Abstract
Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.
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33.1
Nat Rev Genetnature reviews genetics
Metadata
LocationEngland
FromNATURE PUBLISHING GROUP

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