MedicGo
Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes.
Metadata
Journalcell38.637Date
2020 May 28
3 months ago
Publication Type
Journal Article
Volume
2020-Jun-25 / 181 : 1626-1642.e20
Author
Friebel E 1, Kapolou K 2, Unger S 1, Núñez NG 1, Utz S 1, Rushing EJ 3, Regli L 4, Weller M 2, Greter M 1, Tugues S 1, Neidert MC 5, Becher B 6
Affiliation
  • 2. Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland.
  • 3. Department of Neuropathology, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland.
  • 4. Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland.
  • 5. Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland.
  • 6. Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Brain malignancies can either originate from within the CNS (gliomas) or invade from other locations in the body (metastases). A highly immunosuppressive tumor microenvironment (TME) influences brain tumor outgrowth. Whether the TME is predominantly shaped by the CNS micromilieu or by the malignancy itself is unknown, as is the diversity, origin, and function of CNS tumor-associated macrophages (TAMs). Here, we have mapped the leukocyte landscape of brain tumors using high-dimensional single-cell profiling (CyTOF). The heterogeneous composition of tissue-resident and invading immune cells within the TME alone permitted a clear distinction between gliomas and brain metastases (BrM). The glioma TME presented predominantly with tissue-resident, reactive microglia, whereas tissue-invading leukocytes accumulated in BrM. Tissue-invading TAMs showed a distinctive signature trajectory, revealing tumor-driven instruction along with contrasting lymphocyte activation and exhaustion. Defining the specific immunological signature of brain tumors can facilitate the rational design of targeted immunotherapy strategies.
Keywords: T cells Tregs brain metastases exhaustion glioma macrophages mass cytometry microglia monocytes tumor microenvironment
Fav
Like
Download
Share
Export
Cite
38.6
Cellcell
Metadata
LocationUnited States
FromCELL PRESS

No Data

© 2017 - 2020 Medicgo
Powered by some medical students