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A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion.
Metadata
Journaldiagnostic pathology2.335Date
2020 Jun 06
5 months ago
Type
Journal Article
Volume
2020-Jun-06 / 15 : 71
Author
Xie X 1, Lin X 1, Liu M 1, Qin Y 1, Ouyang M 1, Li S 1, Gu Y 2, Chen S 3, Xiang J 3, Zhou C 4
Affiliation
  • 2. Department of Respiratory Pathology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, China.
  • 3. Burning Rock Biotech, Guangzhou, 510300, China.
  • 4. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, 151 Yanjiang Road, Guangzhou, 510120, China. [email protected]
Doi
PMIDMESH
Abstract
BACKGROUND: Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted therapy available for this disease. Therefore, the optimal treatment regimen of this tumor needs to be established.
CASE PRESENTATION: Here we present a case of a 68-year-old patient with stage IVB primary myoepithelial carcinoma of the lung who harbored EGFR exon 19 deletion and KRAS mutation and underwent icotinib targeted therapy, achieving partial response (PR) with progression free survival (PFS) of 3 months.
CONCLUSION: To our knowledge, this study describes the first documented case of primary myoepithelial carcinoma lung cancer patient harboring EGFR exon 19 deletion and KRAS mutation, and showed clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) treatment in this patient.
Keywords: EGFR 19del Icotinib Lung Myoepithelial carcinoma Salivary gland type tumor
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Diagn Patholdiagnostic pathology
Metadata
LocationEngland
FromBMC

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