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Morbidity and mortality in critically ill patients with invasive group A streptococcus infection: an observational study.
Metadata
Journalcritical care6.407Date
2020 Jun 06
2 months ago
Publication Type
Research Support, Non-U.S. Gov't
Journal Article
Volume
2020-06-06 / 24 : 302
Author
Björck V 1, Påhlman LI 2, Bodelsson M 3, Petersson AC 4, Kander T 3
Affiliation
  • 2. Skåne University Hospital, Department of Clinical Sciences Lund, Infection Medicine, Lund University, SE-221 85, Lund, Sweden.
  • 3. Skåne University Hospital, Department of Clinical Sciences Lund, Anaesthesiology and Intensive Care, Lund University, SE-221 85, Lund, Sweden.
  • 4. Clinical Microbiology Laboratory, Region Skåne, SE-221 85, Lund, Sweden.
Doi
PMIDMESH
Abstract
BACKGROUND: Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe critically ill patients with severe sepsis or septic shock due to invasive GAS (iGAS) and compare them with other patients with severe sepsis or septic shock.
METHODS: Adult patients admitted to a general intensive care unit (ICU) in Sweden (2007-2019) were screened for severe sepsis or septic shock according to Sepsis 2 definition. Individuals with iGAS infection were identified. The outcome variables were mortality, days alive and free of vasopressors and invasive mechanical ventilation, maximum acute kidney injury score for creatinine, use of continuous renal replacement therapy and maximum Sequential Organ Failure Assessment score during the ICU stay. Age, Simplified Acute Physiology Score (SAPS 3) and iGAS were used as independent, explanatory variables in regression analysis. Cox regression was used for survival analyses.
RESULTS: iGAS was identified in 53 of 1021 (5.2%) patients. Patients with iGAS presented a lower median SAPS 3 score (62 [56-72]) vs 71 [61-81]), p <  0.001), had a higher frequency of cardiovascular cause of admission to the ICU (38 [72%] vs 145 [15%], p <  0.001) and had a higher median creatinine score (173 [100-311] vs 133 [86-208] μmol/L, p <  0.019). Of the GAS isolates, 50% were serotyped emm1/T1 and this group showed signs of more pronounced circulatory and renal failure than patients with non-emm1/T1 (p = 0.036 and p = 0.007, respectively). After correction for severity of illness (SAPS 3) and age, iGAS infection was associated with lower mortality risk (95% confidence interval (CI) of hazard ratio (HR) 0.204-0.746, p <  0.001). Morbidity analyses demonstrated that iGAS patients were more likely to develop renal failure.
CONCLUSION: Critically ill patients with iGAS infection had a lower mortality risk but a higher degree of renal failure compared to similarly ill sepsis patients. emm1/T1 was found to be the most dominant serotype, and patients with emm1/T1 demonstrated more circulatory and renal failure than patients with other serotypes of iGAS.
Keywords: Group A streptococcus Intensive care unit Sepsis emm1/T1-type
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6.4
Crit Carecritical care
Metadata
LocationEngland
FromBMC

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