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Immunology of COVID-19: Current State of the Science.
Metadata
Journalimmunity22.553Date
2020 May 06
6 months ago
Type
Review
Research Support, N.I.H., Extramural
Journal Article
Volume
2020-06-16 / 52 : 910-941
Author
Vabret N 1, Britton GJ 2, Gruber C 2, Hegde S 2, Kim J 2, Kuksin M 2, Levantovsky R 2, Malle L 2, Moreira A 2, Park MD 2, Pia L 2, Risson E 2, Saffern M 2, Salomé B 2, Esai Selvan M 2, Spindler MP 2, Tan J 2, van der Heide V 2, Gregory JK 2, Alexandropoulos K 2, Bhardwaj N 2, Brown BD 2, Greenbaum B 2, Gümüş ZH 2, Homann D 2, Horowitz A 2, Kamphorst AO 2, Curotto de Lafaille MA 2, Mehandru S 2, Merad M 3, Samstein RM 4, Sinai Immunology Review Project 5
Affiliation
  • 2. Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 3. Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: [email protected]
  • 4. Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: [email protected]
  • 5. Sinai Immunology Review Project
Doi
PMIDMESH
Animals
Betacoronavirus
Coronavirus Infections
Disease Susceptibility
Humans
Immunity, Innate
Immunologic Memory
Inflammation
Lymphocytes
Myeloid Cells
Pandemics
Pneumonia, Viral
Abstract
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
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22.6
Immunityimmunity
Metadata
LocationUnited States
FromCELL PRESS

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