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Intracerebral Astrocytoma in a Horse.
Metadata
Journaljournal of comparative pathology0.994Date
2020 Apr 22
6 months ago
Type
Journal Article
Volume
2020-May / 177 : 1-4
Author
Cavasin JP 1, Miller AD 2, Duhamel GE 1
Affiliation
  • 2. Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, New York, USA. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
An 8-year-old Anglo-European gelding with progressive neurological signs was humanely destroyed and submitted for necropsy examination. The right parietal cortex was disrupted by a well-demarcated, intraparenchymal, 1.5 cm diameter, tan, homogeneous, dense mass. Microscopical examination was consistent with an astrocytoma, which was confirmed on the basis of strong immunohistochemical labelling for glial fibrillary acidic protein. The neoplastic population lacked immunolabelling for oligodendrocyte transcription factor 2. Labelling for ionized calcium binding adaptor molecule 1 highlighted large numbers of reactive microglia throughout the proliferation and in the adjacent neuroparenchyma. While rare, primary brain tumours should be considered as a differential in horses presenting with progressive neurological signs.
Keywords: astrocytoma glial fibrillary acidic protein horse immunohistochemistry
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J Comp Patholjournal of comparative pathology
Metadata
LocationEngland
FromELSEVIER SCI LTD

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