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Histopathological and Immunohistochemical Characteristics of Thyroid Carcinoma in the Dog.
Metadata
Journaljournal of comparative pathology0.994Date
2020 May 25
5 months ago
Type
Journal Article
Volume
2020-May / 177 : 34-41
Author
Soares LMC 1, Pereira AHB 1, de Campos CG 1, Rocha LS 1, Dos Santos TÁ 1, Souza MA 1, Jark PC 2, Pescador CA 3
Affiliation
  • 2. Department of Medical Clinics, University of Brazil, Fernandópolis, São Paulo, Brazil.
  • 3. Laboratory of Veterinary Pathology, Federal University of Mato Grosso, Bairro Boa Esperança, Cuiabá, Mato Grosso, Brazil. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Thyroid carcinomas are a common form of endocrine neoplasia in dogs. In the present study, we combined histopathology with immunohistochemistry (IHC) to search for the presence of oestrogen receptor alpha (ORα), Cox-2 and Ki67 in canine thyroid carcinomas. Forty-eight thyroid carcinomas were diagnosed throughout the study period. Thyroglobulin and calcitonin IHC distinguished between thyroid tumours with a follicular and medullary (C-cell) origin, respectively. IHC-based diagnosis showed that 42 (87.50%) of the cases were follicular cell carcinoma. In these cases, the follicular-compact pattern was the most frequent (n = 20/42; 47.62%) and six cases (12.5%) were medullary cell (C-cell) carcinomas. Both medullary (C-cell) and follicular carcinomas expressed Ki67 and Cox-2. No differences were observed between medullary and follicular carcinomas with respect to expression of Ki67 (P = 0.34) and Cox-2 (P = 0.9523) markers. A total of 4.17% (n = 2/48) of thyroid carcinomas showed positive nuclear labelling for ORα, suggesting that oestrogen does not directly participate in the pathogenesis of canine thyroid neoplasia.
Keywords: dog immunohistochemistry thyroid carcinoma
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J Comp Patholjournal of comparative pathology
Metadata
LocationEngland
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