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The applicability of high-speed counter current chromatography to the separation of natural antioxidants.
Metadata
Journaljournal of chromatography a4.049Date
2020 May 01
3 months ago
Publication Type
Review
Journal Article
Volume
2020-Jul-19 / 1623 : 461150
Author
Gong Y 1, Huang XY 2, Pei D 3, Duan WD 1, Zhang X 1, Sun X 1, Di DL 4
Affiliation
  • 2. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P.R. China. Electronic address: [email protected]
  • 3. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P.R. China; Center of Resource Chemical and New Material, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Qingdao, P.R. China.
  • 4. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P.R. China. Electronic address: [email protected]
Doi
PMIDMESH
Antioxidants
Biphenyl Compounds
Chromatography, High Pressure Liquid
Countercurrent Distribution
Humans
Hydrogen-Ion Concentration
Picrates
Solvents
Abstract
Antioxidants play an essential role in human health, as they have been found to be capable of lowering the incidence of many diseases, such as cancer and angiocardiopathy. Currently, more attention is paid to natural antioxidants because of the possible insecurity of synthetic antioxidants. Thus, the development of efficient techniques or methods to separate antioxidants from natural sources is requested urgently. High-speed counter current chromatography (HSCCC) is a unique support-free liquid-liquid chromatographic technique and has been widely applied in the field of separation of natural products. In this review, we summarize and analyze the related researches on the application of HSCCC in the separation of various natural antioxidants so far. The purpose of the article is to provide a certain theoretical support for the separation of natural antioxidants by HSCCC, and to make full use of advantages of HSCCC in the separation of bioactive components. In particular, some key problems associated with the separation strategies, the structural categories of natural antioxidants, solvent system choices, and the application of different elution modes in HSCCC separation, are summarized and commented. We expect that the content reviewed can offer more evidence for the development of the field of natural antioxidants separation, so as to achieve large-scale preparation of natural antioxidants.
Keywords: High-speed counter current chromatography Natural antioxidants Separation
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4.0
J Chromatogr Ajournal of chromatography a
Metadata
LocationNetherlands
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