MedicGo
Chiral stationary phase based on cellulose derivative coated polymer microspheres and its separation performance.
Metadata
Journaljournal of chromatography a4.049Date
2020 May 20
5 months ago
Type
Journal Article
Volume
2020-Jul-19 / 1623 : 461154
Author
Li L 1, Yuan XT 1, Shi ZG 2, Xu LY 3
Affiliation
  • 2. College of chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China; Hubei Key Laboratory of Processing and Application of Catalytic materials, Huanggang Normal University, China. Electronic address: [email protected]
  • 3. Hubei Key Laboratory of Processing and Application of Catalytic materials, Huanggang Normal University, China.
Doi
PMIDMESH
Cellulose
Chromatography, High Pressure Liquid
Epoxy Compounds
Methacrylates
Microspheres
Phenylcarbamates
Polymers
Porosity
Silicon Dioxide
Stereoisomerism
Triazoles
Vinyl Compounds
Abstract
Chiral stationary phases (CSPs) have always been research hotspot in enantiomer separation. Currently, most of the CSPs are based on silica platform. In this research, monodisperse, porous glycidyl methacrylate-divinylbenzene copolymer particles (poly(GMA-DVB)) were designed and prepared. Then the GMA was further reacted with ethylenediamine to introduce amino groups onto the polymer, which provide anchoring sites for cellulose derivatives. Herein, Cellulose-tris (3,5-dimethylphenylcarbamate) (CDMPC) was successfully coated onto the polymer microspheres, achieving a stable and successful CSP. The porous structure and the surface moieties of the CSPs were studied in detail. The chromatographic separation was optimized. Hexaconazole,methyl DL-mandelate,benzoin and tebuconazole have been successfully separated on the CSP column, with column efficiency as high as 10,200 plates/m, which is comparable with some silica-based CSPs. The research has indicated that the poly(GMA-DVB) is a promising candidate for constructing CSPs for chiral separation.
Keywords: Coated-type chiral stationary phase Enantioseparation Poly(GMA-DVB) Porous polymer microspheres
Fav
Like
Download
Share
Export
Cite
4.0
J Chromatogr Ajournal of chromatography a
Metadata
LocationNetherlands
FromELSEVIER

No Data

© 2017 - 2020 Medicgo
Powered by some medical students