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A polymeric solid-phase microextraction fiber for the detection of pharmaceuticals in water samples.
Metadata
Journaljournal of chromatography a4.049Date
2020 May 16
3 months ago
Publication Type
Journal Article
Volume
2020-Jul-19 / 1623 : 461171
Author
Wang Y 1, Jie Y 1, Hu Q 2, Yang Y 3, Ye Y 2, Zou S 1, Xu J 4, Ouyang G 2
Affiliation
  • 2. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, PR China.
  • 3. South China Sea Resource Exploitation and Protection Collaborative Innovation Center, School of Marine Sciences, Sun Yat-sen University, Zhuhai, 519082, PR China. Electronic address: [email protected]
  • 4. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, PR China. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
A novel disposable styrene based solid-phase microextraction (SPME) fiber was synthesized for the detection of lipid-lowering and antihypertensive drugs in real aquatic environment. Styrene and poly(ethylene glycol) diacrylate were co-polymerized on quartz fibers by thermal polymerization in capillary molds. The polymeric fiber possessed a homogeneous, dense as well as porous surface, showing excellent chemical and mechanical stability. The performance of the fiber was evaluated through the extraction of seven pharmaceuticals by coupling SPME with high performance liquid chromatography-tandem mass spectrometry under the optimized extraction conditions. The extraction efficiency of the fiber was up to 278 times of PDMS fiber and the enrichment factors ranged from 55 to 1183. The limits of detection were in the range from 1.7 ng L-1 to 11.7 ng L-1, with good reproducibility. Moreover, the fiber was used in the real water samples of the Pearl River Delta. The recoveries of the target analytes from river water and sea water samples at different spiked concentrations were in the range from 84.1% to 133.4% and from 81.5% to 105.5%, respectively.
Keywords: High performance liquid chromatography-tandem mass spectrometry Lipid-lowering and antihypertensive drugs Polymeric fiber Solid-phase microextraction
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4.0
J Chromatogr Ajournal of chromatography a
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