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Uncovering an Organ's Molecular Architecture at Single-Cell Resolution by Spatially Resolved Transcriptomics.
Metadata
Journaltrends in biotechnology14.343Date
2020 Jun 03
2 months ago
Publication Type
Review
Journal Article
Volume
2020-Jun-03 / :
Author
Liao J 1, Lu X 1, Shao X 1, Zhu L 2, Fan X 3
Affiliation
  • 2. The Save Sight Institute, Faculty of Medicine and Health, the University of Sydney, Sydney, NSW 2000, Australia.
  • 3. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China; The Save Sight Institute, Faculty of Medicine and Health, the University of Sydney, Sydney, NSW 2000, Australia. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Revealing fine-scale cellular heterogeneity among spatial context and the functional and structural foundations of tissue architecture is fundamental within biological research and pharmacology. Unlike traditional approaches involving single molecules or bulk omics, cutting-edge, spatially resolved transcriptomics techniques offer near-single-cell or even subcellular resolution within tissues. Massive information across higher dimensions along with position-coordinating labels can better map the whole 3D transcriptional landscape of tissues. In this review, we focus on developments and strategies in spatially resolved transcriptomics, compare the cell and gene throughput and spatial resolution in detail for existing methods, and highlight the enormous potential in biomedical research.
Keywords: fluorescence in situ hybridization in situ sequencing single-cell RNA-seq spatial reconstruction spatial transcriptomics spatially resolved transcriptomics
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14.3
Trends Biotechnoltrends in biotechnology
Metadata
LocationEngland
FromELSEVIER SCIENCE LONDON

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