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Recombinant protein subunit vaccine reduces puerperal metritis incidence and modulates the genital tract microbiome.
Metadata
Journaljournal of dairy science3.333Date
2020 Jun 03
4 months ago
Type
Journal Article
Volume
2020-Aug / 103 : 7364-7376
Author
Meira EBS 1, Ellington-Lawrence RD 1, Silva JCC 1, Higgins CH 1, Linwood R 2, Rodrigues MX 1, Bringhenti L 1, Korzec H 1, Yang Y 1, Zinicola M 1, Bicalho RC 3
Affiliation
  • 2. Merck Animal Health, De Soto, KS 66018.
  • 3. Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853-6401. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
The objective of this study was to evaluate the efficacy of 3 vaccine formulations containing proteins (FimH, leukotoxin, and pyolysin), inactivated whole cells (Escherichia coli, Fusobacterium necrophorum, and Trueperella pyogenes), or both, in the prevention of postpartum uterine diseases. A randomized clinical trial was conducted at a commercial dairy farm; 800 heifers were assigned into 1 of 4 different treatment groups: control, vaccine 1 (bacterin and subunit proteins), vaccine 2 (bacterin), and vaccine 3 (recombinant subunit proteins), and each heifer received a subcutaneous injection of its respective treatment at 240 ± 3 and 270 ± 3 d of gestation. Vaccination significantly reduced the incidence of puerperal metritis when compared with control (9.1% vs. 14.9%, respectively; odds ratio 0.51). Additionally, vaccine 3 was found to reduce the incidence of puerperal metritis when compared with the control (8.0% vs. 14.9%, respectively; odds ratio 0.46). Reproduction was improved for metritic cows that were vaccinated, and the effect was stronger for cows that were treated with vaccine 3. In general, vaccination decreased the total vaginal bacterial load and decreased the vaginal load of F. necrophorum by 9 d in milk. Vaccination reduced the prevalence of puerperal metritis in the first lactation of dairy cows, leading to less metritic disease and improved reproduction.
Keywords: Fusobacterium necrophorum metritis microbiome reproduction vaccination
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J Dairy Scijournal of dairy science
Metadata
LocationUnited States
FromELSEVIER SCIENCE INC

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