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A systematic review and meta-analysis of magnetic resonance imaging and ultrasound guided fusion biopsy of prostate for cancer detection-Comparing transrectal with transperineal approaches.
Metadata
Journalurologic oncology-seminars and original investigations2.882Date
2020 Jun 03
4 months ago
Type
Review
Journal Article
Volume
2020-08 / 38 : 650-660
Author
Loy LM 1, Lim GH 2, Leow JJ 3, Lee CH 4, Tan TW 5, Tan CH 6
Affiliation
  • 2. Clinical Research and Innovation Office, Tan Tock Seng Hospital, Singapore.
  • 3. Department of Urology, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore.
  • 4. Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore.
  • 5. Department of Urology, Tan Tock Seng Hospital, Singapore.
  • 6. Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore; Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Targeted biopsy using multiparametric magnetic resonance imaging increases the detection rate of clinically significant prostate cancer (csCaP). In this meta-analysis, we compare the diagnostic accuracy of transrectal (TR) vs transperineal (TP) approaches for MRI-guided software fusion biopsy (FB) in the detection of csCaP. A literature search was performed in PubMed, Cochrane and Embase electronic databases up until July 2019 following the preferred reporting items for systematic review and meta-analysis system. The pooled sensitivity and specificity of either approach was evaluated using radical prostatectomy or systematic biopsies with ≥24 biopsy cores to be the reference standard. Fourteen papers with a total of 2002 patients were selected. Seven hundred and sixty-five patients underwent TR FB, while 1,387 underwent TP FB. One hundred and fifty of the patients underwent both TR and TP approaches. Both approaches were similar in terms of sensitivity (TR vs. TP: 0.81 vs 0.80) and specificity (TR vs. TP: 0.99 vs 0.95). In terms of likelihood ratios and diagnostic odds ratio, TR performed better than TP approach. The area under the receiving operator curve for both approaches was similar (0.91 vs 0.88 respectively). However, there was substantial heterogeneity across the studies for both approaches. TP and TR approaches to software-based FB yield similar diagnostic performance for the detection of csCaP. When deciding on the approach, physicians should consider other inherent features of either technique that suit their practice.
Keywords: Fusion biopsy Magnetic resonance imaging Prostate cancer Transperineal Transrectal
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Urol Oncolurologic oncology-seminars and original investigations
Metadata
LocationUnited States
FromELSEVIER SCIENCE INC

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