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A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children.
Metadata
Journaljournal of infection and public health2.447Date
2020 May 27
5 months ago
Type
Case Report
Volume
2020-Jun / 13 : 883-886
Author
Chen M 1, Fan P 2, Liu Z 3, Pan R 4, Huang S 5, Li J 6, Zhao D 7
Affiliation
  • 2. Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: [email protected]
  • 3. Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: [email protected]
  • 4. Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, China. Electronic address: [email protected]
  • 5. Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, China. Electronic address: [email protected]
  • 6. Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, China. Electronic address: [email protected]
  • 7. Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: [email protected]
Doi
PMIDMESH
Asymptomatic Infections
Betacoronavirus
Child
China
Coronavirus Infections
Family
Female
Humans
Male
Mothers
Pandemics
Pneumonia, Viral
Thorax
Abstract
Information on SARS-CoV-2 asymptomatic infection and infectivity in children is limited. In this study, we aimed to report the epidemiological and clinical characteristics of a familial cluster infection including children with SARS-CoV-2. On February 1, 2020, two children(case 1 and case 2), an 8-year-old girl and a 9-year-old boy, were admitted to the isolation ward in Xiangyang Central Hospital, Hubei province, China, with the diagnosis of COVID-19. Before admission, they had been staying at home with their father and never contacted with any confirmed patients except their mother (case 3) who returned from Wuhan on January 22. Both case 1 and case 2 got mild symptoms. Case 3 did not develop any symptoms until February 6, 2020, with an asymptomatic period of 15 days. She was transferred to ICU and administered multiple treatment according to the disease progression and chest CT manifestations. Her nucleic acid test turned positive until Feb 21, 2020, 15 days after symptoms onset, 30 days after her return from Wuhan. Our data showed that patients with SARS-CoV-2 may have the ability to transmit during their asymptomatic period even with the negative of viral nucleic acid in pharyngeal swabs.
Keywords: Asymptomatic infections COVID-19 Children SARS-CoV-2 Transmission
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J Infect Public Healthjournal of infection and public health
Metadata
LocationEngland
FromELSEVIER SCIENCE LONDON

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