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Computed Tomography Parameters and Estimated Glomerular Filtration Rate Formulas for Peridonation Living Kidney Donor Assessment.
Metadata
Journaltransplantation proceedings0.784Date
2020 Jun 04
4 months ago
Type
Journal Article
Volume
2020-Oct / 52 : 2278-2283
Author
Rasała J 1, Szczot M 2, Kościelska-Kasprzak K 3, Szczurowska A 4, Poznański P 3, Mazanowska O 3, Małkiewicz B 5, Dębiński P 5, Krajewska M 3, Kamińska D 3
Affiliation
  • 2. Faculty of Medicine Wroclaw Medical University, Wrocław, Poland.
  • 3. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
  • 4. Department of General Radiology, Interventional Radiology, and Neuroradiology, Wroclaw Medical University, Wrocław, Poland.
  • 5. Department of Urology and Oncological Urology, Wroclaw Medical University, Wrocław, Poland.
Doi
PMIDMESH
Abstract
BACKGROUND: Renal function is usually described by the estimated glomerular filtration rate (eGFR). The standard method used for living kidney donor evaluation in our center is the 24-hour urine creatinine clearance (CrCl) and kidney morphology assessment with computed tomography (CT). The aim of the study was the analysis of the correlation of CrCl with 15 published eGFR formulas and morphologic CT parameters to choose the most accurate kidney function estimation method before and after donation.
METHODS: The study included 39 living donors (18 male and 21 female, aged 32-69 years; mean age, 51.4 [SD, 9.7] years). The eGFR was estimated using Cockcroft-Gault, Modification of Diet in Renal Disease 7, Modification of Diet in Renal Disease 4, Chronic Kidney Disease Epidemiology Collaboration, Mayo Clinic, Nankivell, Bjornsson, Davis-Chandler, Edward-Whyte, Walser, Gates, Hull, Jelliffe-1, Jelliffe-2, or Mawer formulas and correlated with CrCl. CT parameters (kidney dimensions, volume, vascularization) were compared with eGFR formulas.
RESULTS: The 25% to 34% (mean, 28.5% [SD, 2.3%]) decrease in eGFR after donation and its 1.5% to 5.0% (mean, 3.2% [SD, 1.0%]) increase over a year were observed. Cockcroft-Gault, Bjornsson, Hull, and Mawer equations (all including serum creatinine, age, sex, and body mass) correlated with predonation CrCl (r = 0.54, 0.53, 0.53, and 0.56, respectively; P < .001). From CT parameters, renal cortex volume correlated with CrCl (r = 0.48, P = .002) as well as the 4 abovementioned equations before donation (r = 0.65, 0.61, 0.64, and 0.74, respectively; P < .001) and during the postdonation period (12-month r = 0.59, 0.54, 0.57, and 0.70 respectively; P < .002).
CONCLUSIONS: The eGFR calculated with equations combining serum creatinine, age, sex, and body mass as well as renal cortex volume are predictive of pre- and postdonation kidney function.
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Transplant Proctransplantation proceedings
Metadata
LocationUnited States
FromELSEVIER SCIENCE INC

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