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Hemolytic Anemia as Presentation of T-Cell Large Granular Lymphocytic Leukemia After Kidney Transplantation: A Case Report.
Metadata
Journaltransplantation proceedings0.784Date
2020 Jun 04
4 months ago
Type
Journal Article
Volume
2020-Jun / 52 : 1617-1618
Author
Alfano G 1, Ferrari A 2, Fontana F 3, Damiano F 3, Solazzo A 2, Mori G 3, Cappelli G 4
Affiliation
  • 2. Surgical, Medical and Dental Department of Morphologic Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.
  • 3. Nephrology Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
  • 4. Surgical, Medical and Dental Department of Morphologic Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy; Nephrology Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
Doi
PMIDMESH
Abstract
T-cell large granular lymphocytic (T-LGL) leukemia is a rare clonal proliferation presenting with cytopenia, splenomegaly, and autoimmune manifestations. It has rarely been described in recipients of solid organ transplants. We report the clinical case of a young kidney transplant recipient that developed T-LGL leukemia 3 years after kidney transplantation. The disorder manifested with a severe form of autoimmune hemolytic anemia in the absence of other laboratory abnormalities. The anemia was successfully treated with an intense course of corticosteroids ands witch of immunosuppressive therapy from a calcineurin inhibitor to sirolimus, a mammalian target of rapamycin inhibitor. Our case shows that autoimmune hemolytic anemia can be a life-threatening manifestation of T-LGL disease. The antiproliferative effects of sirolimus may be useful in the treatment of symptoms of T-LGL leukemia in kidney transplantation.
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Transplant Proctransplantation proceedings
Metadata
LocationUnited States
FromELSEVIER SCIENCE INC

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