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Oxidative stress pathways of air pollution mediated toxicity: Recent insights.
Metadata
Journalredox biology9.986Date
2020 May 23
4 months ago
Type
Research Support, N.I.H., Extramural
Review
Journal Article
Volume
2020-07 / 34 : 101545
Author
Gangwar RS 1, Bevan GH 1, Palanivel R 1, Das L 1, Rajagopalan S 2
Affiliation
  • 2. Cardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Ambient air pollution is a leading environmental cause of morbidity and mortality globally with most of the outcomes of cardiovascular origin. While numerous mechanisms are proposed to explain the link between air pollutants and cardiovascular events, the evidence supports a role for oxidative stress as a critical intermediary pathway in the transduction of systemic responses in the cardiovascular system. Indeed, alterations in vascular function are a critical step in the development of cardiometabolic disorders such as hypertension, diabetes, and atherosclerosis. This review will provide an overview of the impact of particulate and gaseous pollutants on oxidative stress from human and animal studies published in the last five years. We discuss current gaps in knowledge and evidence to date implicating the role of oxidative stress with an emphasis on inhalational exposures. We conclude with the identification of gaps, and an exhortation for further studies to elucidate the impact of oxidative stress in air pollution mediated effects.
Keywords: Air pollution Lung inflammation Oxidative stress Particulate matter Reactive oxygen species Redox reaction
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Redox Biolredox biology
Metadata
LocationNetherlands
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