MedicGo
Multicentric, prospective observational data show sperm capacitation predicts male fertility, and cohort comparison reveals a high prevalence of impaired capacitation in men questioning their fertility.
Metadata
Journalreproductive biomedicine online3.218Date
2020 May 01
5 months ago
Type
Journal Article
Volume
2020-Jul / 41 : 69-79
Author
Sharara F 1, Seaman E 2, Morris R 3, Schinfeld J 4, Nichols J 4, Sobel M 4, Lee A 4, Somkuti S 4, Hirshberg S 4, Budinetz T 4, Barmat L 4, Palermo G 5, Rosenwaks Z 5, Bar-Chama N 6, Bodie J 7, Nichols J 8, Payne J 8, McCoy T 8, Tarnawa E 8, Whitman-Elia G 8, Weissmann L 9, Doukakis M 10, Hurwitz J 10, Leondires M 10, Murdock C 10, Ressler I 10, Richlin S 10, Williams S 10, Wosnitzer M 11, Butcher M 12, Kashanian J 13, Ahlering P 14, Aubuchon M 14, Ostermeier GC 15, Travis AJ 16
Affiliation
  • 2. New Jersey Urology, Millburn NJ, USA.
  • 3. IVF1, Naperville IL, USA.
  • 4. Abington Reproductive Medicine, Abington PA, USA.
  • 5. Weill Cornell Medicine, Ronald O. Perelman & Claudia Cohen Center for Reproductive Medicine, New York NY, USA.
  • 6. RMA New York, New York NY, USA.
  • 7. Department of Urology, University of Minnesota, Minneapolis MN, USA.
  • 8. Piedmont Reproductive Endocrinology Group, Greenville SC, USA.
  • 9. South Jersey Fertility Center, Marlton NJ, USA.
  • 10. RMA Connecticut, Norwalk CT, USA.
  • 11. Yale New Haven Health/Northeast Medical Group, Fairfield CT, USA.
  • 12. Park Nicollet Sexual Medicine & Male Infertility Clinic, St Louis Park MN, USA.
  • 13. Weill Cornell Medicine, Urology, New York NY, USA.
  • 14. MCRM Fertility, Chesterfield MO, USA.
  • 15. Androvia LifeSciences, Mountainside NJ, USA.
  • 16. Master of Public Health Program, Cornell University, Ithaca NY. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
RESEARCH QUESTIONS: Can a previously defined relationship between sperm capacitation and the probability of a man generating pregnancy within three cycles, prospectively predict male fertility in diverse clinical settings? A second study asked, what is the prevalence of impaired sperm fertilizing ability in men questioning their fertility (MQF), and does this relate to traditional semen analysis metrics?
DESIGN: In the multicentric, prospective observational study, data (n = 128; six clinics) were analysed to test a published relationship between the percentage of fertilization-competent, capacitated spermatozoa (Cap-Score) and probability of generating pregnancy (PGP) within three cycles of intrauterine insemination. Logistic regression of total pregnancy outcomes (n = 252) assessed fit. In the cohort comparison, Cap-Scores of MQF (n = 2155; 22 clinics) were compared with those of 76 fertile men.
RESULTS: New outcomes (n = 128) were rank-ordered by Cap-Score and divided into quintiles (25-26 per group); chi-squared testing revealed no difference between predicted and observed pregnancies (P = 0.809). Total outcomes (n = 252; 128 new + 124 previous) were pooled and the model recalculated, yielding an improved fit (P < 0.001). Applying the Akaike information criterion found that the optimal model used Cap-Score alone. Cap-Scores were performed on 2155 men (with semen analysis data available for 1948). To compare fertilizing ability, men were binned by PGP (≤19%, 20-29%, 30-39%, 40-49%, 50-59%, ≥60%). Distributions of PGP and the corresponding Cap-Scores were significantly lower in MQF versus fertile men (P < 0.001). Notably, 64% of MQF with normal volume, concentration and motility (757/1183) had PGP of 39% or less (Cap-Scores ≤31), versus 25% of fertile men.
CONCLUSIONS: Sperm capacitation prospectively predicted male fertility. Impaired capacitation affects many MQF with normal semen analysis results, informing diagnosis versus idiopathic infertility.
Keywords: Andrology Assisted reproduction Diagnostic Infertility Pregnancy Real world data Real world evidence
Fav
Like
Download
Share
Export
Cite
3.2
Reprod Biomed Onlinereproductive biomedicine online
Metadata
LocationNetherlands
FromELSEVIER SCI LTD

No Data

© 2017 - 2020 Medicgo
Powered by some medical students