MedicGo
TRPM7 is overexpressed in human IBD-related and sporadic colorectal cancer and correlates with tumor grade.
Metadata
Journaldigestive and liver disease3.57Date
2020 Jun 03
4 months ago
Type
Journal Article
Volume
2020-Jun-03 / :
Author
Pugliese D 1, Armuzzi A 1, Castri F 2, Benvenuto R 2, Mangoni A 2, Guidi L 1, Gasbarrini A 3, Rapaccini GL 1, Wolf FI 4, Trapani V 5
Affiliation
  • 2. UOC Anatomia Patologica, Dipartimento di Scienze della vita e Sanità pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.
  • 3. Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Dipartimento di Medicina e Chirurgia Traslazionale, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.
  • 4. Istituto di Patologia Generale, Dipartimento di Medicina e Chirurgia Traslazionale, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: [email protected]
  • 5. Istituto di Patologia Generale, Dipartimento di Medicina e Chirurgia Traslazionale, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
BACKGROUND: Inflammatory bowel disease (IBD) predisposes to colorectal cancer (CRC) with some specific features that distinguish it from sporadic CRC. Magnesium (Mg) homeostasis is severely compromised in IBD patients, which may affect both inflammation and tumor development. Efficient transcellular Mg transport in intestinal cells depends on the transient receptor potential melastatin (TRPM) channels type 6 and 7, but their expression has never been investigated in the context of IBD-related CRC.
AIMS: We sought to study the expression pattern of TRPM6 and TRPM7 in CRC, and to compare IBD-related cases to sporadic cases.
METHODS: TRPM6 and TRPM7 protein expression was evaluated by immunohistochemistry in surgical specimens from 16 IBD and 13 NON-IBD CRC patients.
RESULTS: TRPM7 expression was higher in tumor tissue than in the adjacent non-neoplastic tissue in both IBD and NON-IBD patients. Overall, adenocarcinomas showed a higher TRPM7 expression than adenomas. TRPM7 expression also positively correlated with tumor grade. Conversely, TRPM6 expression was higher in tumor tissues in both IBD and NON-IBD CRC, but it did not correlate with tumor stage or grade.
CONCLUSIONS: We report a possible participation of TRPM6 and 7 in both IBD-related and sporadic CRC and suggest that TRPM7 might serve as a marker of malignant transformation and lack of differentiation.
Keywords: Biomarker Colorectal cancer IBD Magnesium Personalized medicine Sporadic TRPM6
Fav
Like
Download
Share
Export
Cite
3.6
Dig Liver Disdigestive and liver disease
Metadata
LocationNetherlands
FromELSEVIER SCIENCE INC

No Data

© 2017 - 2020 Medicgo
Powered by some medical students