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Management of T1 colorectal cancers detected at screening colonoscopy: A study from the French national screening programme.
Metadata
Journaldigestive and liver disease3.57Date
2020 Jun 03
4 months ago
Type
Journal Article
Volume
2020-Aug / 52 : 909-917
Author
Grainville T 1, Bretagne JF 2, Piette C 3, Rousseau C 4, Bordet M 1, Cosson M 3, Lièvre A 5
Affiliation
  • 2. Rennes 1 University, 35000, Rennes, France. Electronic address: [email protected]
  • 3. ADECI 35 (Association pour le Dépistage des Cancers en Ille-et-Vilaine), 35040, Rennes, France.
  • 4. Department of Biostastics, University Hospital, 35033, Rennes, France.
  • 5. Department of Gastroenterology, University Hospital, 35033, Rennes, France; Rennes 1 University, 35000, Rennes, France; ADECI 35 (Association pour le Dépistage des Cancers en Ille-et-Vilaine), 35040, Rennes, France; COSS (Chemistry Oncogenesis Stress Signaling), UMR_S 1242, Rennes, France.
Doi
PMIDMESH
Abstract
AIM: The main aim of this study was to examine the management strategies that were used and to determine the outcomes (survival and recurrence rate) of screen-detected T1-CRC.
METHODS: Medical records from 207 patients with T1-CRC diagnosed through the French national screening programme in one district from 2003 to 2015 were analysed. The 5-year overall, CRC-specific and CRC-free survival were calculated for the whole cohort and for the 3 groups treated by endoscopic resection (ER) alone, ER followed by subsequent surgery (ERSS), and primary surgery (PS).
RESULTS: Of the 207 patients, 81 (39%) underwent PS, and 126 (61%) underwent primary ER, of whom 82 (64%) underwent subsequent surgery. The 5-year overall and cancer-specific survival rates were 95.5% (95% CI, 90.8; 97.9) and 98.8% (95% CI, 95.4; 99.7%), respectively. Long-term cancer-specific mortality and recurrence crude rates were 2.4% and 5.6%, respectively. The 5-year CRC-free survival rate was 96.1% (95% CI, 91.8; 98.1%) and did not differ amongst the 3 groups (ER alone, ERSS and PS).
CONCLUSION: This study demonstrates the good prognosis of screen-detected T1-CRC, regardless of the treatment strategy used. But, there is a room to improve the screening programme quality with regard to the management of screen-detected CRC.
Keywords: Colorectal cancer prognosis Colorectal cancer screening Endoscopic therapy Surgical treatment T1 colorectal cancer
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3.6
Dig Liver Disdigestive and liver disease
Metadata
LocationNetherlands
FromELSEVIER SCIENCE INC

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