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Design, development and assessment of an essential oil based slow release vaporizer against mosquitoes.
Metadata
Journalacta tropica2.555Date
2020 Jun 04
4 months ago
Type
Journal Article
Volume
2020-Oct / 210 : 105573
Author
Hazarika H 1, Tyagi V 2, Krishnatreyya H 2, Roy PK 2, Islam J 2, Chakraborty S 3, Gogoi N 4, Kishor S 2, Bhutia YD 2, Goyary D 2, Karmakar S 2, Dwivedi SK 2, Zaman K 4, Chattopadhyay P 5
Affiliation
  • 2. Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur-784001, Assam, India.
  • 3. Department of Food Engineering and Technology, Tezpur University, Tezpur-784028, Assam, India.
  • 4. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, India.
  • 5. Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur-784001, Assam, India. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Mosquitoes (Diptera; Culicidae) are a biting nuisance and are of economic and health importance, especially for people living in tropical countries like India. Given the environmental concerns and health hazards of synthetic insecticides, development of natural products for the control of mosquito and mosquito-borne diseases are needed. In view of this, an essential oil based novel liquid vaporizer formulation with citronella and eucalyptus oils has been developed using a computer aided Artificial Neural Network and Particle Swarm Optimization (ANN-PSO) algorithm approach, aiming to predict the best optimized formulation (OF). Following the development, OF was characterized by Fourier Transform-Infra Red (FT-IR) spectroscopy and gas chromatography-mass spectroscopy (GC-MS). The efficacy of the OF was assessed against two major mosquito vectors viz. Anopheles stephensi and Aedes albopictus using a Peet-Grady chamber. Finally, toxicological impacts of the OF following its inhalation were investigated as per the Organization for Economic Co-operation and Development (OECD) guidelines. The results revealed all the ideal characteristics of the OF which were found to provide a slow release of up to 450 h at room temperature. Most importantly, the OF, exhibited 50% mosquito knock down (KT50) within 11.49±1.34 and 14.15±2.15 min against An. stephensi and Ae. albopictus respectively. Toxicity assessment showed a non toxic nature of the OF following inhalation. Thus the present development would be beneficial for controlling both An. stephensi and Ae. albopictus without any associated health hazards.
Keywords: Citronella oil Eucalyptus oil Mosquito repellent Safety assessment Vaporizer formulation
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Acta Tropacta tropica
Metadata
LocationNetherlands
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