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CT Manifestations and Clinical Characteristics of 1115 Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-analysis.
Metadata
Journalacademic radiology2.488Date
2020 May 05
5 months ago
Type
Review
Meta Analysis
Journal Article
Volume
2020-07 / 27 : 910-921
Author
Wan S 1, Li M 2, Ye Z 1, Yang C 1, Cai Q 3, Duan S 4, Song B 5
Affiliation
  • 2. Department of Cardiology, Guangdong Provincial People's Hospital, No. 106, Zhongshan 2nd Road, Guangzhou, 510000, China.
  • 3. Department of Ultrasound, The General Hospital of the People's Liberation Army, No. 28 Fuxing road, Haidian district, Beijing 100089, China.
  • 4. GE Healthcare China. No.1, Huatuo road, Pudong new town, Shanghai 210000, China.
  • 5. Department of Radiology, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, PR China. Electronic address: [email protected]
Doi
PMIDMESH
Adult
Betacoronavirus
Biomarkers
Bronchography
C-Reactive Protein
Clinical Laboratory Techniques
Coronavirus Infections
Cough
Diarrhea
Female
Fever
Humans
Leukopenia
Lung
Lymphopenia
Male
Middle Aged
Myalgia
Pandemics
Pneumonia, Viral
Reverse Transcriptase Polymerase Chain Reaction
Thorax
Tomography, X-Ray Computed
Abstract
RATIONALE AND OBJECTIVES: We aimed to assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19).
MATERIALS AND METHODS: A systematic literature search of PubMed, EMBASE, the Cochrane Library, and Web of Science was performed to identify studies assessing CT features, clinical, and laboratory results of COVID-19 patients. A single-arm meta-analysis was conducted to obtain the pooled prevalence and 95% confidence interval (95% CI).
RESULTS: A total of 14 articles (including 1115 patients) based on chest CT images were retrieved. In the lesion patterns on chest CTs, we found that pure ground-glass opacities (GGO) (69%, 95% CI 58-80%), consolidation (47%, 35-60%) and "air bronchogram sign" (46%, 25-66%) were more common than the atypical lesion of "crazy-paving pattern" (15%, 8-22%). With regard to disease extent and involvement, 70% (95% CI 46-95%) of cases showed a location preference for the right lower lobe, 65% (58-73%) of patients presented with ≥3 lobes involvement, and meanwhile, 42% (32-53%) of patients had involvement of all five lobes, while 67% (55-78%) of patients showed a predominant peripheral distribution. An understanding of some important CT features might be helpful for medical surveillance and management. In terms of clinical features, muscle soreness (21%, 95% CI 15-26%) and diarrhea (7%, 4-10%) were minor symptoms compared to fever (80%, 74-87%) and cough (53%, 33-72%).
CONCLUSION: Chest CT manifestations in patients with COVID-19, as well as its main clinical characteristics, might be helpful in disease evolution and management.
Keywords: COVID-19 CT manifestations Clinical features Laboratory Meta-analysis
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2.5
Acad Radiolacademic radiology
Metadata
LocationUnited States
FromELSEVIER SCIENCE INC

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