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The use of the chick embryo CAM assay in the study of angiogenic activiy of biomaterials.
Metadata
Journalmicrovascular research2.73Date
2020 Jun 05
4 months ago
Type
Review
Journal Article
Volume
2020-Sep / 131 : 104026
Author
Ribatti D 1, Annese T 2, Tamma R 2
Affiliation
  • 2. Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Doi
PMIDMESH
Abstract
The chick embryo chorioallantoic membrane (CAM) is a highly vascularized extraembryonic membrane, which carries out several functions during embryonic development, including exchange of respiratory gases, calcium transport from the eggshell, acid-base homeostasis in the embryo, and ion and water reabsorption from the allantoic fluid. Due to its easy accessibility, affordability and given that it constitutes an immunodeficient environment, CAM has been used as an experimental model for >50 years and in particular it has been broadly used to study angiogenesis and anti-angiogenesis. This review article describes the use of the CAM assay as a valuable assay to test angiogenic activity of biomaterials in vivo before they are further investigated in animal models. In this context, the use of CAM has become an integral part of the biocompatibility testing process for developing potential biomaterials.
Keywords: Angiogenesis Biocompatibility Chorioallantoic membrane Tissue engineered construct Tissue regeneration
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2.7
Microvasc Resmicrovascular research
Metadata
LocationUnited States
FromACADEMIC PRESS INC ELSEVIER SCIENCE

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