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Tectal Low-Grade Glioma with H3 K27M Mutation.
Metadata
Journalworld neurosurgery1.829Date
2020 Jun 04
4 months ago
Type
Case Report
Volume
2020-Sep / 141 : 91-100
Author
Sumi K 1, Shijo K 1, Igarashi T 1, Yamamuro S 1, Sasano M 1, Oshima H 1, Ishige T 2, Honma T 2, Yagasaki H 3, Yoshino A 4
Affiliation
  • 2. Division of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
  • 3. Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • 4. Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan. Electronic address: [email protected]nihon-u.ac.jp.
Doi
PMIDMESH
Abstract
BACKGROUND: In the revised World Health Organization 2016 classification of central nervous system tumors, "diffuse midline glioma, H3 K27M-mutant" has been added as a new diagnostic entity. However, some confusion exists concerning this diagnostic entity because H3 K27M-mutant diffuse midline glioma is diagnosed with grade IV regardless of morphologic phenotype. Furthermore, the significance of H3 K27M mutation in tumors that aren't typical "diffuse midline glioma, H3 K27M-mutant," such as those with an unusual location and nontypical histology, remains unclear.
CASE DESCRIPTION: To elucidate further such unusual tumors, we describe here a rare case of pediatric low-grade glioma located in the tectum, which was morphologically a pilocytic astrocytoma (PA) with genetically H3 K27M mutation but no microvascular proliferation, necrosis, mitoses, or other genetic alterations, insofar as we were able to observe. At the latest follow-up, 28 months after surgery, radiotherapy, and chemotherapy, the patient was found to be free from any neurologic deficits and MRI demonstrated that the tumor was stable without tumor regrowth. This case might be identified as "diffuse midline glioma, H3 K27M-mutant", grade IV, when applying only the current World Health Organization 2016 classification. In addition, we discuss the morphologically benign gliomas harboring the H3 K27M mutation based on the literature.
CONCLUSIONS: We describe here a rare case and present a short literature review of circumscribed/nondiffuse gliomas, particularly in PA with H3 K27M mutation. However, the significance of H3 K27M mutation for PA remains unclear, so further studies and clinical data are needed to elucidate the biology and optimal treatment of such tumors.
Keywords: Diffuse midline glioma H3 K27M mutation Pediatric tumor Pilocytic astrocytoma Tectal glioma
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World Neurosurgworld neurosurgery
Metadata
LocationUnited States
FromELSEVIER SCIENCE INC

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