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Actin binding proteins, actin cytoskeleton and spermatogenesis - Lesson from toxicant models.
Metadata
Journalreproductive toxicology3.121Date
2020 Jun 04
4 months ago
Type
Journal Article
Volume
2020-Jun-04 / 96 : 76-89
Author
Wang L 1, Yan M 2, Wu S 3, Wu X 4, Bu T 4, Wong CKC 5, Ge R 6, Sun F 4, Cheng CY 7
Affiliation
  • 2. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China; The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY, 10065, United States. Electronic address: [email protected]
  • 3. The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY, 10065, United States; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
  • 4. Institute of Reproductive Medicine, Nantong University School of Medicine, Nantong, Jiangsu, 226001, China.
  • 5. Department of Biology, Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon, Hong Kong, China.
  • 6. The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
  • 7. The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY, 10065, United States. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Actin cytoskeleton is crucial to support spermatogenesis in the mammalian testis. However, the molecular mechanism(s) underlying changes of actin cytoskeletal organization in response to cellular events that take place across the seminiferous epithelium (e.g., self-renewal of spermatogonial stem cells, germ cell differentiation, meosis, spermiogenesis, spermiation) at specific stages of the epithelial cycle of spermatogenesis remain largely unexplored. This, at least in part, is due to the lack of suitable study models to identify the crucial regulatory proteins and to investigate how these proteins work in concert to support actin dynamics. Much of the information on the role of actin binding proteins in the literature, namely the actin bundling proteins, actin nucleation proteins and motor proteins, are either findings based on genetic models or morphological analyses. While this information is helpful to delineate the function of these proteins to support spermatogenesis, they are not helpful to identify the regulatory signaling proteins, the signaling pathways and the cascade of events to modulate actin cytoskeleton dynamics. Recent studies based on the use of toxicant models, both in vitro and in vivo, however, have bridged this gap by identifying putative regulatory and signaling proteins of actin cytoskeleton. Herein, we summarize and critically evaluate these findings. We also provide a hypothetical model by which actin cytoskeletal dynamics in Sertoli cells are regulated, which in turn supports spermatid transport across the seminiferous epithelium, and at the blood-testis barrier (BTB) during the epithelial cycle of spermatogenesis.
Keywords: Actin binding proteins Actin bundling proteins Actin cytoskeleton Actin nucleation proteins Actin-based motor proteins Spermatogenesis Testis
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Reprod Toxicolreproductive toxicology
Metadata
LocationUnited States
FromPERGAMON-ELSEVIER SCIENCE LTD

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