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Detection of African genotype in Hyalomma tick pools during Crimean Congo hemorrhagic fever outbreak, Rajasthan, India, 2019.
Metadata
Journalvirus research2.934Date
2020 Jun 04
4 months ago
Type
Journal Article
Volume
2020-Sep / 286 : 198046
Author
Sahay RR 1, Dhandore S 2, Yadav PD 3, Chauhan A 4, Bhatt L 5, Garg V 6, Gupta N 7, Nyayanit DA 8, Shete AM 9, Singh R 10, Patil S 11, Sharma H 12, Meena D 13, Gupta J 14, Gawande P 15, Kalele K 16, Jain R 17, Mali D 18, Malhotra B 19, Nag V 20, Khatri PK 21, Kaur H 22, Vijay N 23, Singh S 24, Gopalakrishnan M 25
Affiliation
  • 2. National Centre of Disease Control, New-Delhi, India. Electronic address: [email protected]
  • 3. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 4. National Centre of Disease Control, New-Delhi, India. Electronic address: [email protected]m.
  • 5. State Disease Diagnostic Centre, Animal Husbandry, Jaipur, Rajasthan India. Electronic address: [email protected]
  • 6. Regional Disease Diagnostic Centre, Animal Husbandry, Jodhpur, Rajasthan India. Electronic address: [email protected]
  • 7. Indian Council of Medical Research, Ansari Nagar, New Delhi, India. Electronic address: [email protected]
  • 8. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 9. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 10. Directorate Medical and Health Services, IDSP, Public Health Department, Government of Rajasthan, India. Electronic address: [email protected]
  • 11. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 12. Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: [email protected]
  • 13. Directorate Medical and Health Services, IDSP, Public Health Department, Government of Rajasthan, India. Electronic address: [email protected]
  • 14. Directorate Medical and Health Services, IDSP, Public Health Department, Government of Rajasthan, India. Electronic address: [email protected]
  • 15. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 16. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 17. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 18. ICMR-National Institute of Virology, Microbial Containment Complex, Sus-Pashan Road, Pune, Maharashtra, India. Electronic address: [email protected]
  • 19. Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: [email protected]
  • 20. All India Institute of Medical Sciences, Jodhpur, Rajasthan India. Electronic address: [email protected]
  • 21. Dr. S.N. Medical College, Jodhpur, Rajasthan, India. Electronic address: [email protected]
  • 22. Department of Health Research, Indian Council of Medical Research, Ansari Nagar, New Delhi, India. Electronic address: [email protected]
  • 23. Department of Health Research, Indian Council of Medical Research, Ansari Nagar, New Delhi, India. Electronic address: [email protected]
  • 24. National Centre of Disease Control, New-Delhi, India. Electronic address: [email protected]
  • 25. Sawai Man Singh Medical College, Jaipur, Rajasthan, India. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
Crimean Congo hemorrhagic fever (CCHF) is a zoonotic viral disease presenting with fever and hemorrhagic manifestations in humans. After several outbreaks of CCHF being reported from Gujarat since 2011 till 2019 and from Rajasthan in 2014 and 2015, the present study reports the CCHF outbreak which was recorded from five human cases in three districts Jodhpur, Jaisalmer, and Sirohi of Rajasthan state since August 2019 till November 2019. A high percent of positivity was recorded in livestock animal samples for the CCHFV IgG antibody. CCHF virus (CCHFV) positive human blood samples and Hyalomma tick pool samples were sequenced using next-generation sequencing method. Two different M segment genotypes, encoding glycoprotein precursor, were identified from tick pools in the study: first from Asian and second from African lineage. The L gene (polymerase) and the S gene (nucleocapsid) clustered in the Asian lineage. The present study illustrates the existence of two different CCHFV lineages being circulating within the Hyalomma tick pools in the Rajasthan state, India. We also observed 3.56% amino acid changes between the death and the survived case of CCHFV in the M gene. This report also sets an alarm to enhance human, tick and livestock surveillance in other districts of Rajasthan and nearby states of India. Biosafety measures, barrier nursing along with the availability of personal protective equipment and ribavirin drug will always be a mainstay in preventing nosocomial infection for proper case management.
Keywords: African CCHF India Rajasthan Recombinant
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