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PPARγ gene Pro12Ala variants reduce the risk of obese individuals to non-alcoholic fatty liver: A study in Uygur Chinese population residing in Northwestern China.
Metadata
Journalclinics and research in hepatology and gastroenterology2.718Date
2020 Jun 03
4 months ago
Type
Journal Article
Volume
2020-Jun-03 / :
Author
Su Y 1, Liu Z 2, Yang L 3, Li Y 4, Jiang S 5, Yao H 6, Du G 7
Affiliation
  • 2. Department of Microrepair and Reconstruction, the First Affiliated Hospital of Xinjiang Medical University, China.
  • 3. Department of abdominal ultrasound, the First Affiliated Hospital of Xinjiang Medical University, China.
  • 4. Public Health School of Xinjiang Medical University, China.
  • 5. Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University, China.
  • 6. Health Management Institute, Xinjiang Medical University, China. Electronic address: [email protected]
  • 7. Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University, China. Electronic address: [email protected]
Doi
PMIDMESH
Abstract
OBJECTIVE: To investigate the association of polymorphisms of Pro12Ala of peroxisome proliferator-activated receptor gamma (PPARγ) gene with clinical and biochemical parameters in Uygur Chinese population with non-alcoholic fatty liver (NAFLD) METHODS: In this case-control study, we recruited 467 NAFLD cases and 524 controls. Examination of abdominal ultrasound, clinical and biochemical profiles, as well as polymerase chain reaction-restriction fragment length polymorphisms of Pro12Ala of PPARγ gene were performed. The association of PPARγ gene Pro12Ala variants with clinical and biochemical parameters was analyzed.
RESULTS: There was no statistically significant difference between NAFLD and control groups in the frequencies of genotypic and allele distribution (P>0.05), while significantly difference of genotypic (P=0.032) and allele (P=0.015) distribution was found between NAFLD and control groups in the obese. Using logistics multivariate regression analysis by adjusting age, sex, body mass index, diabetes, hyperuricemia and dyslipidemia, both Pro12Ala and Ala12Ala polymorphisms were not associated with the presence of NAFLD. However, above two polymorphisms were found to be related to NAFLD in obesity group (odds ratio=0.442, P=0.031 and odds ratio=0.039, P=0.010, respectively) CONCLUSION: In Uygur Chinese population, PPARr gene Ala variants reduce the risk of NAFLD in obese individuals.
Keywords: Non-alcoholic fatty liver Peroxisome proliferator-activated receptor-γ.
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Clin Res Hepatol Gastroenterolclinics and research in hepatology and gastroenterology
Metadata
LocationFrance
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