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Natural history of COVID-19 and current knowledge on treatment therapeutic options.
Metadata
Journalbiomedicine & pharmacotherapy4.545Date
2020 Jul 03
3 months ago
Type
Review
Journal Article
Volume
2020-Sep / 129 : 110493
Author
Dos Santos WG 1
Affiliation

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Doi
PMIDMESH
Animals
Antiviral Agents
Betacoronavirus
Coronavirus Infections
Drug Design
Humans
Pandemics
Pneumonia, Viral
Public Health
Viral Vaccines
Abstract
Despite intense research there is currently no effective vaccine available against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 and responsible for the COVID-19 pandemic. This infectious and communicable disease has become one of the major public health challenges in the world. The clinical management of COVID-19 has been limited to infection prevention and control measures associated with supportive care such as supplemental oxygen and mechanical ventilation. Meanwhile efforts to find an effective treatment to inhibit virus replication, mitigate the symptoms, increase survival and decrease mortality rate are ongoing. Several classes of drugs, many of them already in use for other diseases, are being evaluated based on the body of clinical knowledge obtained from infected patients regarding to the natural history and evolution of the infection. Herein we will provide an updated overview of the natural history and current knowledge on drugs and therapeutic agents being tested for the prevention and treatment of COVID-19. These include different classes of drugs such as antiviral agents (chloroquine, ivermectin, nitazoxanide, hydroxychloroquine, lopinavir, remdesivir, tocilizumab), supporting agents (Vitamin C, Vitamin D, azithromycin, corticosteroids) and promising investigational vaccines. Considering the controversies and excessive number of compounds being tested and reported in the literature we hope that this review can provide useful and updated consolidated information on potential drugs used to prevent, control and treat COVID-19 patients worldwide.
Keywords: Anakinra Convalescent plasma Corticosteroids Hydroxychloroquine SARS-CoV-2 Vaccine
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4.5
Biomed Pharmacotherbiomedicine & pharmacotherapy
Metadata
LocationFrance
FromELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

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