Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19.
Journaljournal of endocrinological investigation3.397Date
2020 Aug 09
a month ago
Journal Article
2020-Aug-09 / :
Carpagnano GE 1, Di Lecce V 1, Quaranta VN 2, Zito A 3, Buonamico E 4, Capozza E 1, Palumbo A 1, Di Gioia G 1, Valerio VN 1, Resta O 1
  • 2. Pneumology Department, "Di Venere" Hospital Bari, Bari, Italy.
  • 3. Cardiology Department, "SS Annunziata" Hospital, Taranto, Italy.
  • 4. Institute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari "Aldo Moro", piazza Giulio Cesare 11, 70125, Bari, Italy. [email protected]
PURPOSE: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis.
METHODS: In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020.
RESULTS: Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019).
CONCLUSIONS: High prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.
Keywords: Acute respiratory failure COVID-19 Mortality risk Vitamin D deficiency
J Endocrinol Investjournal of endocrinological investigation

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