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A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society.
Metadata
Journaleuropean journal of pediatrics2.305Date
2020 Aug 10
a month ago
Type
Journal Article
Volume
2020-Aug-10 / :
Author
Oncel MY 1, 2, Akın IM 3, Kanburoglu MK 4, Tayman C 5, Coskun S 6, Narter F 7, Er I 8, Oncan TG 9, Memisoglu A 10, Cetinkaya M 11, Oguz D 12, Erdeve O 13, Koc E 14, Neo-Covid Study Group 15
Affiliation
  • 2. Division of Neonatology, Tepecik Training and Research Hospital, University of Health Sciences, Konak, 35180, İzmir, Turkey. [email protected]
  • 3. Division of Neonatology, Umraniye Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.
  • 4. Department of Pediatrics, Division of Neonatology, School of Medicine, Rize Recep Tayyip Erdoğan University, Rize, Turkey.
  • 5. Division of Neonatology, Ankara City Hospital, Ministry of Health, Ankara, Turkey.
  • 6. Division of Neonatology, Sancaktepe Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.
  • 7. Division of Neonatology, Kartal Dr. Lütfi Kırdar City Hospital, Ministry of Health, İstanbul, Turkey.
  • 8. Division of Neonatology, Kocaeli Derince Training and Research Hospital, University of Health Sciences, Kocaeli, Turkey.
  • 9. Division of Neonatology, Bornova Türkan Özilhan State Hospital, Ministry of Health, İzmir, Turkey.
  • 10. Department of Pediatrics, Division of Neonatology, School of Medicine, Marmara University, İstanbul, Turkey.
  • 11. Division of Neonatology, Kanuni Sultan Süleyman Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.
  • 12. Division of Neonatology, Haseki Training and Research Hospital, Ministry of Health, İstanbul, Turkey.
  • 13. Department of Pediatrics, Division of Neonatology, School of Medicine, Ankara University, Ankara, Turkey.
  • 14. Department of Pediatrics, Division of Neonatology, School of Medicine, Gazi University, Ankara, Turkey.
  • 15. Neo-Covid Study Group
Doi
PMIDMESH
Abstract
Limited data are available on pregnant women with COVID-19 and their neonates. We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Pregnant women (n = 125) who had a positive RT-PCR test and their newborns were enrolled. Cesarean section, prematurity, and low-birthweight infant rates were 71.2%, 26.4%, and 12.8%, respectively. Eight of 125 mothers (6.4%) were admitted to an intensive care unit for mechanical ventilation, among whom six died (4.8%). Majority of the newborns (86.4%) were followed in isolation rooms in the NICU. Four of 120 newborns (3.3%) had a positive RT-PCR test result. Although samples taken on the first day were negative, one neonate became positive on the second day and the other two on the fifth day. Sample from deep tracheal aspirate was positive on the first day in an intubated case.Conclusion: COVID-19 in pregnant women has important impacts on perinatal and neonatal outcomes. Maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission, and low rate of breastfeeding show that family support should be a part of the care in the NICU.Trial registration: ClinicalTrials.gov identifier: NCT04401540 What is Known: • The common property of previous reports was the conclusions on maternal outcomes, rather than neonatal outcomes. • Published data showed similar outcomes between COVID-19 pregnant women and others. What is New: • Higher maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission especially in a case with deep tracheal aspiration during the intubation, and the possible role of maternal disease severity on the outcomes are remarkable findings of this study. • In contrast to recommendation for breastfeeding, parents' preference to formula and expressed breast milk due to anxiety and lack of information shows that family support should be a part of the care in the NICU.
Keywords: COVID-19 Newborn Pregnancy SARS-CoV-2
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Eur J Pediatreuropean journal of pediatrics
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