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The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells.
Metadata
Journalbritish journal of haematology5.518Date
1975-Jun
Publication Type
Journal Article
Volume
1975-Jun / 30 : 225-31
Author
Worathumrong N , Grimes AJ
DoiPMIDMESH
Blood Glucose
Erythrocytes
Glucosephosphate Dehydrogenase Deficiency
Humans
Hydrogen-Ion Concentration
Methylene Blue
Pentosephosphates
Sodium Salicylate
Abstract
The effect of the major metabolite of aspirin, namely salicylic acid, upon the pentose phosphate pathway (PPP) of normal and G6PD-deficient red cells has been studied. Salicylic acid was shown to inhibit this pathway in proportion to the amount present. At any concentration of this substance there was greater inhibition of the PPP in G6PD-deficient than in normal red cells.
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5.5
Br J Haematolbritish journal of haematology
Metadata
LocationEngland
FromWILEY

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