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Rapid test for screening of narcotic analgesics in mice.
Metadata
JournalPol J Pharmacol PharmNot FoundDate
1979-Nov-Dec
Type
Journal Article
Volume
1979-Nov-Dec / 31 : 605-8
Author
Herman ZS , Felińska W
Doi
Not Found
PMIDMESH
Analgesics, Opioid
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Edetic Acid
Female
Mice
Abstract
50 microliter of a solution of 0.35 N NH4OH containing 2.325% EDTA and 0.837% NaCl injected intradermally in mice elicited reproducible short term behavior typical for nociceptive stimulus. This behavior was inhibited specifically by narcotic analgesics. This procedure may be used as a specific test for screening and for dose--effect studies of narcotic analgetic drugs in mice.
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Pol J Pharmacol PharmPolish journal of pharmacology and pharmacy
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