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Hemodynamic effects of somatostatin in insulin-dependent diabetic subjects.
Metadata
JournalActa Diabetol LatNot FoundDate
1979-Oct-Dec
Type
RCT
Journal Article
Trial
Volume
1979-Oct-Dec / 16 : 331-7
Author
Giugliano D , Cacciapuoti F , Verza M , Rosato G , Varricchio M
DoiPMIDMESH
Adult
Cardiac Volume
Diabetes Mellitus, Type 1
Female
Heart Rate
Hemodynamics
Humans
Insulin
Male
Middle Aged
Somatostatin
Stroke Volume
Abstract
The aim of the present study was to evaluate possible hemodynamic effects of somatostatin in insulin-dependent diabetic subjects. For this purpose, 7 insulin-requiring juvenile-onset diabetics were submitted to a short-term infusion of cyclic somatostatin (250 micrograms/h, over 2 h) or saline in randomized order. Somatostatin infusion resulted in a progressive and significant decrease in heart rate, stroke volume, cardiac index and velocity circumferential fiber; on the other hand, left ventricular ejection time was augmented by somatostatin. None of these effects was seen in the saline control study. We conclude that somatostatin exerts a negative inotropic effect in insulin-dependent diabetes.
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