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Summary of laboratory studies on the antibacterial activity of cefaclor.
Metadata
Journalinfection3.04Date
1979
Type
Journal Article
Comparative Study
Volume
1979 / 7 Suppl 6 : 557-61
Author
Preston DA
DoiPMIDMESH
Animals
Bacteria
Bacterial Infections
Cefaclor
Cephalexin
Cephalothin
Drug Evaluation
Drug Stability
Enterobacteriaceae
Haemophilus
Methods
Mice
Microbial Sensitivity Tests
Streptococcus pneumoniae
beta-Lactamases
Abstract
Laboratory aspects of cefaclor, a new orally-effective cephalosporin antibiotic, are summarized. On the basis of data from a variety of studies, the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin. Cefaclor has a significant potency advantage over cephalexin against many Enterobacteriaceae, Haemophilus sp. and Streptococcus pneumoniae. Bacteria that are susceptible to cefaclor are killed by concentrations at or near the inhibitory concentration. In vitro enzymatic hydrolysis experiments have shown that cefaclor is a relatively good substrate for several beta-lactamases. Orally administered cefaclor is effective in protection of mice from the lethal effects of intraperitoneal challenges with cefaclor-susceptible bacteria. The chemical instability of cefaclor, test medium composition and inoculum density influence the results of in vitro susceptibility tests with cefaclor. Methods for routine susceptibility testing are described.
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Infectioninfection
Metadata
LocationGermany
FromSPRINGER HEIDELBERG

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