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Spontaneous motility of isolated mesosalpinx-free isthmic and ampullar segments from human oviducts, and the influences of indomethacin and prostacyclin (PGI2).
Metadata
JournalInt. J. Fertil.Not FoundDate
1979
Type
Journal Article
Volume
1979 / 24 : 281-5
Author
Gimeno AL , Sterin-Speziale N , Landa A , Zapata C , Gimeno MF
Doi
Not Found
PMIDMESH
Epoprostenol
Fallopian Tubes
Female
Humans
In Vitro Techniques
Indomethacin
Movement
Abstract
The spontaneous contractile activity of isolated mesosalpinx-deprived isthmic and ampullar segments from estrogen dominated human oviducts and the influences of indomethacin, prostaglandin F2-alpha, (PGF2-alpha), E1 (PGE1), E2 (PGE2) and prostacyclin (PGI2) on their motility, were explored. Indomethacin enhanced significantly the Isometric Developed Tension (I.D.T.) of the isthmic but not the ampullar region. On the other hand, a single and identical concentration (10(-6) M) of PGE1 and PGI2 depressed the ampulla whereas PGE2 and PGF2-alpha enhanced its contractions. In the isthmus, PGE1, PGE2, and PGF2-alpha augmented whereas PGI2 diminished the I.D.T. Dose-response curves of PGI2 demonstrated a dose-dependent depression of I.D.T. and contractile frequency of both ampullar and isthmic regions. Furthermore, in the isthmus PGI2 resulted in a biphasic action on resting basal tone (depressing at low and augmenting at high concentrations), whereas in the ampulla only a progressive dose-dependent decline, was observed. The results suggest that a prostaglandin with inhibitory capacity, presumably PGI2, may be synthesized by the human isthmus and play some role in the reduced spontaneous activity observed under estrogenic dominance.
Keywords: Biology Clinical Research Endocrine System Fallopian Tubes Genitalia Genitalia, Female Oviductal Effects Physiology Prostaglandins Research Methodology Tubal Effects Tubal Motility Effects Urogenital System
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Int. J. Fertil.International journal of fertility
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