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Factors affecting the bluetongue virus neutralizing antibody response and the reaction between virus and antibody.
Metadata
Journalonderstepoort journal of veterinary research0.979Date
1979-Jun
Type
Journal Article
Volume
1979-Jun / 46 : 111-6
Author
van der Walt NT
Doi
Not Found
PMIDMESH
Animals
Antibodies, Viral
Antibody Formation
Antigen-Antibody Reactions
Bluetongue virus
Hydrogen-Ion Concentration
Immunoglobulin G
Immunoglobulin M
Microscopy, Electron
Neutralization Tests
Rabbits
Reoviridae
Temperature
Abstract
A study was made of different aspects of the bluetongue virus neutralizing antibody response and the reaction between the virus and antibody. Optimum neutralization was obtained in a 2mM Tris-HCl buffer, pH 9,0, at a temperature of 4 degrees C. The reaction of virus and antibody could be demonstrated by electron microscopy in the formation of clumps which were shown to be serotype specific. It was found that both IgM and IgG antibodies can neutralize the virus, but that IgM reached its maximum level sooner after infection than IgG.
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Onderstepoort J Vet Resonderstepoort journal of veterinary research
Metadata
LocationSouth Africa
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