MedicGo
Trypanosoma brucei infection in nude mice: B lymphocyte function is suppressed in the absence of T lymphocytes.
Metadata
Journalparasite immunology2.054Date
1979-Spring
Type
Journal Article
Volume
1979-Spring / 1 : 39-48
Author
Clayton CE , Ogilvie BM , Askonas BA
DoiPMIDMESH
Animals
B-Lymphocytes
Cell Division
Female
Immunoglobulins
Immunosuppression
Lipopolysaccharides
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Nude
Spleen
Splenomegaly
T-Lymphocytes
Trypanosomiasis, African
Abstract
B lymphocyte function was assessed in outbred nude mice and nu/+controls infected with Trypanosoma brucei brucei. On day 10 of the infection in outbred nu/nu mice in which the initial wave of parasites was strongly controlled, B cell function was unaltered on enhanced compared with uninfected animals or infected nu/+. In other nu/nu mice unable to control the initial parasitaemia, thymidine incorporation and Ig secretion by spleen cells were increased on day 10 and their response to lipopolysaccharide in vitro negated. By day 15 however, even the spleen cells of infected nu/nu which controlled the initial wave of parasites were proliferating and secreting Ig on removal from the mice and they were unable to respond to LPS in vitro. These experiments confirm results of a previous study of B cell function in T cell-depleted mice (Askonas et al. 1979). T. b. brucei infection of mice causes both enhanced Ig production and suppression of the ability of B cells to respond to mitogen even in the absence of T cells, but the presence of T cells may accelerate the changes which occur in B lymphocytes following this infection.
Fav
Like
Download
Share
Export
Cite
2.1
Parasite Immunolparasite immunology
Metadata
LocationEngland
FromWILEY

No Data

© 2017 - 2020 Medicgo
Powered by some medical students