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Demonstration of two new endogenous "benzodiazepine-like" compounds from brain.
Metadata
Journalpsychiatry research2.118Date
1979-Oct
Type
Journal Article
Volume
1979-Oct / 1 : 121-30
Author
Marangos PJ , Clark R , Martino AM , Paul SM , Skolnick P
DoiPMIDMESH
Animals
Anti-Anxiety Agents
Benzodiazepines
Brain Chemistry
Cattle
In Vitro Techniques
Liver
Myocardium
Pituitary Gland
Receptors, Drug
Abstract
The recent report that purines are competitive inhibitors of specific [3H] diazepam binding to brain membranes has prompted further work concerning the characterization of possible endogenous ligands for the benzodiazepine receptor. In this report, two previously undescribed fractions capable of apparent competitive inhibition of [3H] diazepam binding are reported. Both factors are heat stable and resistant to proteolytic degradation. The larger factor (approximately 700 to 30,000 daltons) is present only in brain and pituitary. The smaller factor (500 to 600 daltons) is found in pituitary, liver, and muscle, but the highest levels are found in brain.
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Psychiatry Respsychiatry research
Metadata
LocationIreland
FromELSEVIER IRELAND LTD

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