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Neuroleptic, antimuscarinic, and antiadrenergic activity of chlorpromazine, thioridazine, and their metabolites.
Metadata
Journalpsychiatry research2.118Date
1979-Oct
Type
Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't
Journal Article
Volume
1979-Oct / 1 : 199-208
Author
Cohen BM , Herschel M , Aoba A
DoiPMIDMESH
Animals
Antipsychotic Agents
Cattle
Chlorpromazine
In Vitro Techniques
Parasympatholytics
Radioligand Assay
Sympatholytics
Thioridazine
Abstract
Chlorpromazine and thioridazine are widely used antipsychotic agents that are extensively metabolized. Parent compounds and metabolites have diverse pharmacologic activities, and differences in patterns of metabolism may explain differences in therapeutic and side effects from individual to individual. Radioreceptor assays were used to determine the neuroleptic, antimuscarinic, and anti-alpha-noradrenergic potency of chlorpromazine, thioridazine, and their metabolites. The results indicate that these metabolites show a wide range of potencies. The spectrum of activity of a metabolite may be quite different from that of its parent compound. The clinical relevance of these findings to individual differences in drug response is discussed. The combined use of radioreceptor assays and chemical assays in future clinical research is proposed.
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Psychiatry Respsychiatry research
Metadata
LocationIreland
FromELSEVIER IRELAND LTD

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