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Dose dependency of the responses in draining lymph nodes and skin to repeated applications of oxazolone. A quantitative and histological study in mice.
Metadata
JournalVirchows Arch., B, Cell Pathol.Not FoundDate
1979-Dec
Type
Journal Article
Volume
1979-Dec / 32 : 21-31
Author
Myking AO
DoiPMIDMESH
Animals
Dose-Response Relationship, Drug
Female
Lymph Nodes
Lymphocytes
Mice
Oxazoles
Oxazolone
Plasma Cells
Skin
Time Factors
Abstract
The skin reactivity and lymph node responses to a large scale of different doses of oxazolone, were followed under continuous stimulation for a period of 12 days. It was found that the lack of a continuous high blast cell activity in the paracortex was a physiological response that could be observed with high dosage as well as with very low dosage. Low doses gave distinct stimulation of the paracortex without any detectable reaction in the cortex and in the medulla. Manifest stimulation of these compartments required considerably higher doses. A marked paracortical response was the only lymph node change required for development of a typical delayed type skin response. When germinal centres and plasma cells had developed, the skin reactivity was also found to change characteristically.
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Virchows Arch., B, Cell Pathol.Virchows Archiv. B, Cell pathology including molecular pathology
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